Conducted by BatStateU
, Started on 2017 -
Completed on 2017
Completed
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Due to the harm imposed by pathogenic bacteria present in the surroundings, there is a growing importance in hand hygiene as the single most essential measure in the prevention, control, and reduction of healthcare acquired infections. Product development and innovation for hand sanitization has been the focus of recent studies for many health professionals. These include modifications of the inactive ingredient and addition of antibacterial agents like plant extracts to maximize antibacterial activity. Passion fruit leaf is long used as medicinal plant and its extract has found to have antibacterial activity due to its phytochemical compounds. This study focuses on formulation of hand sanitizer with passion fruit leaf extract as active ingredient. The antibacterial properties of formulated hand sanitizers with 1%, 3%, and 5% of passion fruit leaf extract was tested against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Trichophyton mentagrophytes using disc-diffusion method and the result of the best formulation was compared with the commercially available hand sanitizer. Properties of the formulated sanitizers such as color, odor, texture, pH, specific density, and viscosity were also determined in the study. All of the three formulations exhibited antibacterial activity against 3 of 5 microorganisms. The results depicted that hand sanitizer with 1%, 3%, and 5% passion fruit leaf extract exhibited antibacterial activity based on mean clearing zone values against Staphylococcus aureus (22mm, 26mm, 26 m), Pseudomonas aeruginosa (15 mm, 16 mm ,18 mm) and Trichophyton mentagrophytes (16 mm, 20 mm, 16 mm). Results obtained that the formulated hand sanitizers have a pH (4.92, 4.59, 4.42), specific density (0.8829, 0.8849, 0.88739), and viscosity (2.2681, 0.0673, 0.0005). In comparison with the commercially available sanitizer, the best formulation with 3% passion fruit leaf extract exhibited greater antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Thus, the results of this study support the incorporation and utilization of plant extracts for formulation of hand sanitizer. However, the researchers recommend that further research and development must be conducted for the improvement of hand sanitizer’s quality.