Conducted by ESSU
, Started on 2018 -
Completed on 2018
Completed
Published
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This study formulated a tablet using cassava and swamp taro starch as disintegrant and areca nut as active anthelmintic agent; the tablet was manually compacted and its physical, mechanical and disintegrating properties were determined. Results showed that the color and odor of both tablets are brown with white specks and odorless, respectively. Both tablets were insoluble to organic and inorganic solvents, but are slightly soluble to alcoholic medium; moreover, both tablets possess the same pH of 6.0. Friability tests showed high friability and a low compressive strength or hardness. Further statistical computations in terms of disintegration showed that cassava starch-based tablet is more rapid in disintegrating than swamp taro starch-based tablet regardless of simulated fluid. These findings indicate that cassava starch can be used as disintegrant, also this also highlights that direct compaction or manual compaction method of tableting gives a tablet lower hardness and higher friability. This study suggests cassava starch is more suitable as disintegrant than swamp taro, and that both starches can be used for veterinary drug development.